GHP Q1 2021

Q1 2021 Happy Hair at Juvida Clinics Taking care of your hair can give a person no small amount of confidence, and it is this confidence that people take with them into all manner of life experiences. However, when a person loses their hair, that does not mean that the confidence has to go altogether. Instead, hope endures in the form of Juvida Clinics. Discover why we awarded this outstanding clinic the title of Most Trusted Hair Transplant Clinic of 2020, the UK, last year.

2 GHP / Q1 2021 Editor’s Note , Welcome to the 2021 Q1 edition of Global Health & Pharma Magazine, providing you with all the latest news and features from across the healthcare and pharmaceutical landscape. Whilst 2020 may have proven to be a very difficult year for many, the healthcare and pharmaceutical industry was certainly pushed to its limits. Yet, just over twelve months on from the start of the pandemic and national lockdowns, there is sign of reprieve and hope that life can begin again. The rollout of vaccines in the fight against COVID-19 has proven to be a success, healthcare and pharmaceutical staff have given everything to help others, and the world is slowly but surely showing signs of returning to normal. Speaking of returning to normal, many people will be yearning to get back to their hairdresser or barber and see to it that their hair is restored to its former glory. For those who have struggled with hair loss, be it genetic or simply pulling it out at the thought of an extended lockdown , the work of Juvida Clinics represents the same kind of hope for people who want their hair back. Juvida Clinics may not be able to bring back the last twelve months, but it can inspire youthfulness and life in its clients, helping them get ready for a return to life as normal with friends and family. There is plenty more success stories such as this one to unpack within these pages, with each company featured delivering its own success through insightful knowledge and fantastic innovation in abundance. For now, we hope that you are staying safe and enjoy reading this latest issue of Global Health & Pharma. Michael Pusey, Editor Phone: +44 (0) 203 970 0018 Website: AI Global Media, Ltd. (AI) takes reasonable measures to ensure the quality of the information on this web site. However, AI will not assume any legal liability or responsibility for the accuracy, correctness or completeness of any information that is available through this web site. If errors are brought to our attention, we will try to correct them. The information available through the website and our partner publications is for your general information and use and is not intended to address any particular finance or investment requirements. In particular, the information does not constitute any form of advice or recommendation by us or any of our partner publications and is not intended to be relied upon by users in making or refraining from making any investment or financial decisions. Appropriate independent advice should be obtained before making any such decision. Any arrangement made between you and any third party named in the site is at your sole risk and responsibility.

GHP / Q1 2021 3 Contents , 4. News 6. Happy Hair at Juvida Clinics 10. Fountain of Youth 12. NINA Medical Makes Marvels 14. Safety First 16. Restoring Your Confidence 17. Global Skin Health Pioneers 18. Celebrating the Beauty of Life 19. Delightful Dentist Secures Success 20. Looking Good! 21. Service with a Smile 22. Helping The Future Generation 23. Sealing Success With Superior Surgery 24. Innovative Solutions 25. A Second Chance At Life 26. Committed To Their Clients 27. Investment And New Approaches Help Boost Clients In The Face Of Covid 28. Luxury Clinic Leads The Way 29. The Champion of Challenger Brands 30. Sterling Solutions for Hair Transplants 31. Amazing Aesthetics Work Achieves Awards 32. Enhancing Beauty with Exceptional Treatments 33. Attracting International Clients Through Its Social Media Fame 34. Fighting Anti-Ageing With Amazing Treatments 35. PR Success Secrets For Small Beauty Firms 36. Star-Studded Skincare 37. Making MedTech Work For All 38. Medical Marvel In Mitigating Strokes 40. Leading Innovators in Diabetes Management Technology – UK 41. Naturally Amazing 42. Innovative Healthcare Solutions 43. Ultimate Success For UV-Based Technology Firm Contents 44. Innovating towards Success 45. Recruitment Specialists Get It Right 46. Man-made Diamond Leads the Way in Next-Generation Cervical Disc Replacement Device 47. Resourceful Researchers! 48. Top Quality Solutions For Hair Loss 49. Weight Loss Success Story! 50. Money Maestros 51. Beauty in Everything 52. Drinks Supplier Secures Success 53. A Leading Example of the Approach to Modern Medical Aesthetics 54. Cosmetic Surgeon Secures Success 55. Luscious Locks 56. Specialist Dermatology in Georgia 57. The Production Powerhouse Behind Beauty 58. Continuity Of Care 59. Global Trailblazers in Locomotive Medicine 60. Accomplishments To Smile About 61. Helping You To Feel and Look Your Best 62. Accentuating This Aesthetic Clinic’s Best Features 63. Smiling With Success 64. Life Force Energy 65. Slimming Success For Medical Marvel 66. A Leading Voice in an Improving Industry 67. The Pioneers Behind Accessible Dermatology 68. The Cream Of The Crop In Advancing Latest Skincare Technology 69. Encouraging Personal Health Worldwide 70. Delivering Drugs Through Brilliant Biomolecular Medicine

4 GHP / Q1 2021 NEWS , The funding comes eight months into CEO Gren Paull’s tenure and follows a series of strategic senior appointments, including former management consultant Kelly Hudson as CSO, and CCO Nick Weston, formerly of O2. Having recently pivoted from hardware to software and undertaken a major rebrand, Lilli’s purpose-led approach and smart technology fulfils a growing need in the UK for independent living, alleviating the pressures of caring for an ageing UK population with long-term health conditions, and advocates accessibility to the technology for all those that need it. The solution uses machine learning to analyse a range of data sources, such as temperature, motion, and power usage. This provides real-time data and insights to those responsible for caregiving to provide reassurance about wellbeing and highlight any causes for concern. As a result, over-stretched health and social care providers can intervene earlier, whilst monitoring at a distance, reducing the need for hospital admissions and lowering costs. Lilli’s technology has already undergone trials with Brent Council and is about to commence a 100-person trial with Dorset County Council, UK health tech company Lilli raises £4.5 million for scale up both through Lilli’s Independent Future Group. The group, formed by Lilli, is a coalition of forward-thinking local authorities and professional care associations which aims to explore the further use of technology and help address the changing needs of care. Discussions are also in progress with 17 local authorities and Clinical Commissioning Groups about additional implementations. Gren Paull, CEO, Lilli, said: “The timing for this new preventative approach to care and integration of our smart technology is crucial in meeting the needs of ageing population, this has only been exacerbated by COVID 19. The role of technology has a vital role to play in the future success of care delivery across the UK and globally.” Robert Forbes Caie, managing partner West Hill Capital, added: “West Hill is delighted to be supporting Lilli enabling them to bring its pioneering preventative technology to the NHS and social care sector. Lilli’s proprietary technology is empowering people to live independently within their own homes for longer, when in the past, an individual’s age, ability or condition would have required constant supervision or care. West Hill seeks to identify companies harbouring strong IP that are potentially globally scalable and we feel that Lilli certainly exhibits these qualities.” Lilli, the UK SaaS company usingmachine learning to revolutionise home care, has raised £4.5 million in a pre-Series A funding round organised byWest Hill Capital that was 50%over-subscribed.

GHP / Q1 2021 5 NEWS , Heavymonthly bleeding, excruciating cramps, abdominal pain evenwhen you’re not menstruating - the symptoms can vary in intensity and frequency, but the cause stays the same. It is endometriosis, a condition that affects one in tenwomen. Endometriosis can bring a lot of pain and evenmore questions, yet there are so few answers. This Endometriosis Awareness Month, Dr Shree Datta, gynaecologist for INTIMINA, a brand dedicated to women’s intimate well-being and breaking taboos, sheds light on the disease. Endometriosis Awareness Month: Everything you need to know about Endometriosis What is Endometriosis? Endometriosis is a state in which the endometrial tissue (tissue that normally lines the uterus) can be found outside the uterus (in the abdomen, ovaries, etc.). There are several theories about why this happens, but none can explain why the cells plant themselves outside the uterus. The most accepted explanation is Sampson’s theory, or the retrograde menstruation theory, which suggests that some of the cells go the opposite way during menstruation – they don’t go out through your vagina, but instead go towards your abdomen where they plant themselves. What is known is that endometriosis occurs most frequently in the pelvic organs and peritoneum, and some studies suggest that 1 in 10 women suffer from it.* How to recognise the symptoms? Living with endometriosis can be very difficult. You could be one of the lucky ones that have asymptomatic endometriosis, so you wander around the world, not even knowing what’s going on inside you because there are no symptoms. But you could also experience painful menstruations, bloating, pain during sex (dyspareunia), pelvic pain, etc. You may be thinking that these symptoms are pretty typical and that every woman feels at least one of them at some point in life. That is what makes the diagnosis tricky. Endometriosis symptoms are everything but specific, so there are many undiagnosed cases, and many women are suffering in silence. Some women experience mild symptoms, but in severe endometriosis, women may also experience pain in between periods and in a minority, it can affect fertility. Bear in mind that the severity of your pain may not reflect the severity of your endometriosis. What causes endometriosis? The cause of endometriosis is still not known, and diagnosing it can be challenging because it shares symptoms with many other conditions. Sometimes doctors don’t even think about endometriosis as a possible explanation of symptoms like abdominal pain and cramps. What is the diagnosis process? As you can imagine, endometriosis symptoms can have a huge impact on your life so it’s not unusual to feel down. You will be referred to a Gynaecologist who will find out your medical background and examine you. You may be asked to keep a diary of your symptoms because it can be difficult to distinguish endometriosis from other medical conditions. We’ll also send you for an ultrasound. Once we have this information, we will consider whether medication will help or we may suggest a laparoscopy - which is key-hole surgery under an anaesthetic - to investigate things further or to treat the endometriosis. In women with severe endometriosis, we may recommend an MRI before considering surgery. Is there any treatment? Possible treatments include medications such as the contraceptive pills, Mirena coil and surgery. In part, it depends on the type and location of your endometriosis and how severe it is. For some women, simple painkillers such as Ibuprofen can be helpful. The contraceptive pill or Mirena coil can also manage symptoms but for others, surgery is helpful. If we consider the combined contraceptive pill, we may suggest that you “tri-cycle” it (take three packs without a break), so that it’s 3 months before you have a period. This can help heal the endometriosis over time. If we consider surgery, we will try to remove and treat all areas of endometriosis. This may be a day case procedure or in more complex cases, require a laparotomy - a cut in your bikini line and a short stay in hospital. We will discuss which option is better for you depending on your symptoms and ultrasound findings; in some cases, you may need a mixture of different treatments. Remember it also depends on other factors - for example, if you are trying to conceive, we would not prescribe the contraceptive pill or the Mirena coil. As well as considering medical treatment, we will also take a look at your diet because endometriosis is stimulated by estrogen, so liver and digestive care through nutrition is important - for example, eating lots of green vegetables and antiinflammatory foods. Reducing the amount of caffeine and alcohol in your diet as well as exercising regularly may also be helpful. Dr Shree Datta comments: “We don’t know the exact cause of endometriosis but it can be incredibly difficult to live with - both physically and emotionally. It’s a long term condition but fortunately, there are treatments for it - so make sure you speak to your Gynaecologist early. Many women are able to manage their symptoms and lead a normal life once they have received the treatment needed, so don’t be embarrassed to seek advice and get help. There are also lots of support groups, charities and online forums who are there to help - endometriosis is common so don’t feel like you have to suffer alone”. Marcella Zanchi, spokesperson for INTIMINA UK adds: “Many women live with pain, not knowing the cause and keeping it a secret, thus making conditions like endometriosis a taboo. Endometriosis should be talked about, so women could know there is a name for their disease and do something to make it easier. It is essential to develop a good relationship with your doctor to communicate your symptoms and feelings freely and clearly.”

6 GHP / Q1 2021 , Jul20210 The world of hair is one that many people approachwith no small amount of caution, whether it be considering a new trim, thinking about a new colour, or making a drastic change to its length. Taking care of your hair can give a person no small amount of confidence, and it is this confidence that people take with them into all manner of life experiences. However, when a person loses their hair, that does not mean that the confidence has to go altogether. Instead, hope endures in the formof Juvida Clinics. Discover why we awarded this outstanding clinic the title of Most Trusted Hair Transplant Clinic of 2020, the UK, last year. Happy Hair at Juvida Clinics Hair is something that many people place a great amount of emphasis on, as it can seriously affect an individual’s confidence and feelings about themselves. For those that lose their hair, whatever the circumstances surrounding that, there can sometimes come feelings of inadequacy or a distinct lack of self-confidence. It is at times like this the team at Juvida Clinics can help restore some of that lost confidence, providing lifechanging hair transplants that result in quality looks and ultimate comfort. The team at Juvida Clinics is wholly dedicated and committed to ensuring that every patient that walks into the clinic is able to receive nothing but the best in terms of natural-looking results that are achieved using the very latest innovations in hair transplant treatment. Being able to look youthful, vibrant, and full of life is exactly what the team strives for, and the clients can have their hairline and confidence restored at the same time. The firm’s name, “Juvida”, is an amalgamation of words that represent what it stands for, with “Juve” acting a prefix to youthfulness, and “Vida” meaning life. This combination of youthfulness and life is what the clinic seeks to give to every client that walks through its doors. Restoring a hairline is about more than just giving someone back their hair; it is about creating a sense of confidence that has possibly been lost with the loss of hair. Juvida Clinics understands that a lack of confidence may also stop people from seeking out the services of the clinic itself. That is why the staff team takes great care and enormous pride in their ability to be caring, professional, and deliver a stress-free service at all times. Ensuring that a patient feels calm enough to seek out professional help regarding their hair loss is imperative to Juvida Clinics, and it has certainly achieved that today. At Juvida Clinics, the facility is a purpose-built clinic that boasts a spa-like feeling for those that are seeking a peaceful and tranquil environment in which to consider their various hair-related choices. The serenity of the facility means that every client feels at ease and comfortable throughout the duration of their consultation, treatment, and aftercare plan. All of the staff members also drive themselves to succeed for their clients. Everything is done for the clients. The hair transplant surgeons themselves are driven by a passion to maintain youthfulness, as per the name of the firm itself. Surgeons always work a key aim of restoring a hairline and, by default, a youthful appearance, and confidence that clients once had. One of the ways that Juvida Clinics ensures that the client feels at ease from the get-go is by offering a free consultation with its knowledgeable team. This no-obligation and totally free consultation represents the perfect opportunity for prospective clients to ask those burning questions and find an ideal treatment that works for them. Hair transplant treatments take many forms and can serve many purposes, and finding the ideal treatment is absolutely imperative. This allows the client to do that before jumping into any decisions about what to do with their hair following a treatment. With treatments that have been meticulously designed to suit all manner of budgets and conditions, Juvida Clinics has quickly carved out a reputation for being the instant choice for many clients, including celebrities. Focusing on several key areas of service, the team at Juvida Clinics specialises in hair loss treatments. What makes the clinic unique to the myriad of others on the market is its ability to treat patients over a long treatment time, actively trying to prevent hair loss on a more permanent basis than its competitors. Rather than treat problems as they arise, the clinic instead seeks to solve the problems on a long-term basis and give clients their confidence and hairline back for good. Juvida Clinics always strives to do what is best for client. Simple, yet effective. It is this philosophy which has seen the firm go from success to success, delivering outstanding service to every client that seeks it. There are a number of treatments that Juvida Clinics offers, and each one offers something different to each patient. When people first begin to look into the possibility of hair transplant surgery, one of the first and most prominent treatments they discover is that of Follicular Unit Extraction, or FUE. Though it may initially appear as quite complex and intimidating, FUE is actually neither of those things and has no reason for the patient to feel anxious. Many individuals around the world have undergone this treatment with great success, and Juvida Clinics can ensure that same success for its patients. FUE is the most common advanced hair transplant technique, and involves the doctor administering a local anaesthetic prior to creating a circular incision around a follicular unit in the donor area.

GHP / Q1 2021 7 The hair unit is then removed from the skin using forceps, before being transplanted to the area that requires extra growth. Small holes are created in the recipient areas, and the follicle units are then reinserted. Post-operative hair growth will occur for up to twelve months after the surgery has been completed, and Juvida Clinics will do everything it possibly can to ensure that every FUE hair transplant results in a natural finish that is tailored to the patient’s exact needs. Understandably, going through

8 GHP / Q1 2021 , a surgery and process such as this is not an easy decision to make, and that is why Juvida Clinics addresses all questions, concerns, and queries at its consultation. The patient’s sense of relaxation, comfort, and confidence are of the utmost importance, and the clinic pays great attention to those areas. FUE may be a popular procedure for so many people that has changed their lives, and it could very well do the same for any patient that chooses it through Juvida Clinics. Another of the key services provided by Juvida Clinics is that of ARTAS hair transplants. ARTAS is a piece of robotic machinery that was developed to perform the FUE procedure with maximum efficiency. The introduction of robotics into this field has revolutionised hair transplantation, for Juvida Clinics is one of a limited number in the UK that can offer robotics-based FUE. What separates ARTAS from regular FUE is that the machine utilises specific algorithms to identity the most suitable follicle units for transplantation, and boasts enough intelligence to choose the number of follicular units for extraction. It is at the very forefront of innovation in machinery and robotics, and Juvida Clinics’ patients can make full use of its fantastic power. Celebrities have also changed the game, with Kim Kardashian being almost single-handedly responsible for the mainstream introduction of Platelet-Rich Plasma (PRP) Treatment, also dubbed the “vampire” treatment. Now, the treatment has become increasingly popular as a method of treating hair thinning and loss, despite being originally introduced as a way of achieving a youthful skin complexion. Today, PRP Treatment can be used as an effective treatment for those in the early stages of hair loss. It can potentially encourage hair regrowth, resulting in visibly thicker-looking hair. There are no allergy risks, and the blood used in the treatment is taken from the patient’s own veins. Rather than be used as a method of regrowing hair, the PRP Treatment is used best on hair that are thinning, rather than those which have already been lost. How exactly does the treatment work though? During the treatment, trained professionals at Juvida Clinics take blood from the patient and process it in a machine. The processed blood is then injected back into the patient, at the site of the scalp hair loss. What happens during the machine process is that the machine removes the plateletrich plasma from red blood cells, which is believed to stimulate new cells. Taking less than forty minutes in its entirety, the full process is considered to be extremely safe and non-invasive. In order to see good results from this PRP Treatment, it is usually recommended that a patient has eight individual sessions of this treatment. However, this can vary and is dependant on the extent of hair loss and the condition of the affected area. Finally, another key procedure that Juvida Clinics can provide is that of Semi-Permanent Scalp Micropigmentation. This is a treatment that is open to almost everyone, including those that have already had a hair transplant and want to further densify their look, or those that have been already deemed ineligible for a hair transplant. Scalp micro-pigmentation is the next best option for patients that fall into these two categories. In practice, it is a non-surgical procedure that can improve the appearance of hair loss. Instead of transplanting hair and bringing it back, the area is simply disguised to look like hair through tattooing pigments to the dermal layer on the skin in order to mimic the appearance of follicles. This process is also perfect for those looking to cover up scars and other imperfections around the hairline. When dealing with the world of hair loss and hair treatment, it pays to have access to the best possible technologies, and that is exactly what Juvida Clinics has done. It is home to the world’s only robotic hair transplant system, called “ARTAS”, and the firm is soon looking to be in a position where it can purchase the NEOGRAFT, a highly advanced piece of machinery that would make Juvida Clinics the only clinic in Europe to have such machinery at its disposal. The clinic has actually spent more than one and a half million on the latest technologies, ensuring that every patient has access to nothing but the best in hair loss and haircare treatment. Technology is one thing, but having the knowledge and expertise to apply that technology in the right ways is another thing entirely. Results are an important part of what Juvida Clinics has to offer to its clients. In order to guarantee that the results delivered are of the highest possible standard, the clinic reviews its clients at three, six, nine, and twelve months after their initial treatment date. If there are obvious gaps, or something fails to meet the exceptional standards that the clinic sets for itself, then the client is able to have those gaps filled in without being charged anything extra. There are no hidden fees or surprising charges that can leave a client with a sour taste in their mouth. Instead, Juvida Clinic guarantees results and the peace of mind that goes with having a beautiful head of hair. Juvida Clinics has also been in a position where it is able to take enormous pride in the awards and industry recognition that it has achieved over the years. Though the clinic’s primary aim is, and always will be, the pursuit of incredible result for its clients, the awards and industry recognition serve to demonstrate that it is doing everything right and achieving the best possible results for its clients. Just recently, in 2019, the clinic received two awards which have only ever been granted to a small number of clinics across the entirety of the world. Last year, Global Health & Pharma Magazine awarded the clinic the title of The UK’s Most Trusted Hair Transplant Clinic 2020, and the successes just continue to come for the clinic and its staff. Outside of the United States, Juvida Clinics is the only clinic in the world to have earned the ARTAS Platinum Status, and it is also an ARTAS Clinical Centre of Excellence. These awards are a fitting testament to the success of the clinic, and could not be awarded to a more deserving facility. The vast amounts of investment in the latest technology and the personability of the staff have all come together in a culmination of clinical excellence that ensures Juvida Clinics will long remain a staple of the hair loss treatment community and industry. Patients can have every option, and the staff’s willing to go above and beyond in administering the latest results shows with these awards. Looking to the future, Juvida Clinics is currently undergoing a rebranding of sorts; a transplant, if you will. No doubt that will soon come to fruition and clients can look forward to a brand new, exciting future for the clinic. Juvida Clinics is also in the process of opening its own academy, where it will train other doctors in the art of hair transplants. With high-profile success cases inspiring more people than ever before to consider hair transplants, this academy will empower and enable doctors to have more open and honest discussions with patients about what their hair transplant needs may be. Ultimately, Juvida Clinics is one of the finest hair loss treatment clinics not just in the United Kingdom, but in the world. Its exclusivity is matched only by the excellence it has achieved over the last several years. By working with some of the latest advancements and the most innovative techniques, Juvida Clinics continues to stand itself apart from the competition and deliver hair loss treatment services that are second to none. It is an outstanding facility, and is fully deserving of this latest success from Global Health and Pharma Magazine. Company: Juvida Clinics Web:

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10 GHP / Q1 2021 , Oct20601 Looking younger for longer is more possible than it ever has been before. The teamat DefenAge®New Skin have achieved amazing success with their new line. Named as 2020’s Most Innovative Skincare Range in GHP’s Global Excellence awards, we thought we’d take a closer look at the firm to see just how they’ve done it. Fountain of Youth Led by technology, driven by a passion for skin, the team at DefenAge have achieved the remarkable with their thrilling, and thriving, new skincare line. Over the last few years, this incredible product has gained traction throughout the professional aesthetic market, becoming a staple of those who work at dermatology and aesthetic surgery practices. DefenAge works through using the latest in innovative skin technology, in this case using the spectrum of immune molecules called defensins in topical cosmetic formulations in a specific range of concentrations effective to provide an anti-aging effect on a global scale. The team at DefenAge have the exclusive rights to the technology, which has a proven impact on visible fine and coarse wrinkles, pore size and visible pigmentation. Even to the untrained eye, the range on offer provides a profound improvement to the health and beauty of skin. The use of defensins has allowed the team to access dormant, relatively young and fresh skin’s master stem cells that are located across the body. When activated, they produce new skin. These cells are usually used during wound healing, which is why it appears so much younger – it is younger. By harnessing the body’s own ability to regenerate skin, it’s possible to have a huge impact without the risks of more damaging work. The use of this technology has never been seen before, which is what makes it such a revolutionary concept. The products offer many of the advantages in time-honored retinols as well as newer but widely used growth-factor containing cosmeceuticals, but without the irritation or inflammation, sunsensitivity, or concerns about neoplasia of the treated skin. It’s the best of both worlds. As with any innovation, a stringent testing regime has guided every step of the team’s development process. DefenAge has completed fifteen clinical studies to establish and confirm the safety and efficacy of their products on people. One of these studies was the most comprehensive and largest clinical study of defensins ever undertaken. This multi-center, double-blind, placebo-controlled clinical trial showed without any doubt that the use of defensins results in a significant improvement in the appearance of skin. One of the earliest priorities of the DefenAge team was the granting of a patent to protect their work from the competition. As such a revolutionary product, it’s little surprise that the team wanted to secure their knowledge as unique within the industry. It has opened the door to a whole new market outside of America, and secured an incredibly powerful skin rejuvenation technology. At the heart of DefenAge has been their Clinical Power Trio, made of three products that are designed to be used in combination to quickly and effectively improve the visual appearance of aging skin without irritation, dryness, or inflammation. The trials that this product was developed on brought about extraordinary change throughout use, with improvement measured at six weeks. Such an impressive product has already generated impressive demand, and it’s a demand that DefenAge has been meeting since its soft launch in 2015. By 2018, more than 300 US-based aesthetic physicians and medispas were able to offer DefenAge as part of their services and in 2020, the team were able to boast products across 1,000 aesthetic medical offices, med spas and dermatologist-driven skin care boutiques within the US. Annual growth for the firm exceeded 100% for the first three years of the business’s existence, with sales in 2017 that went well over $2.4M. Since then, it’s clear that sales of the product have increased significantly in the last five years, with the new clinical proof of the firm’s success encouraging more to take it on as a vital part of their operations. The team at DefenAge took the decision to take an omnichannel approach to the brand, reaching into both the retail and e-commerce sectors. This decision has allowed DefenAge into many different areas that it would not previously have access to, feeding on demand in the retail sector to feed demand in terms of e-commerce. While experimentation is vital to guaranteeing safety, especially when applying products to skin, the team do their best to ensure that they are operating in an ethical and fair manner. This means that products do not contain animal- or humanoriginated ingredients, parabens, formaldehyde-releasing preservatives, sulfates, mineral oils, colorants, phthalates or BPA. It goes without saying that their products are not tested on animals either. 2020 saw the fifth anniversary of the team’s products, reaching just the latest step in a series of impressive milestones. What had started as a single antiaging cream became a skincare revolution that took a more holistic produce to proceedings. To celebrate the brand’s fifth anniversary, DefenAge added the limited-edition LUXE KIT to the firm’s already illustrious range of products. This advanced technology-driven skin care collection includes the brand’s signature Clinical Power Trio, award-winning eye cream and two complimentary gifts in the form of the brand’s facial cleanser and a luxurious 100% silk pillowcase. It’s clear that technology has driven the success of DefenAge, but what is clear is that the evidence of the product’s success speaks for itself. Finding a way of allowing the body to solve any skin problems that have arisen has proven to be a stroke of genius. In short, DefenAge offers a solution that is clean, harmless and produced incredible results. It’s a company worth watching in order to know what they’ll do next! Company: DefenAge New Skin Web:

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12 GHP / Q1 2021 , Nov20615 Medicine and healthcare are industries that are always subject to the ever-moving world of innovation. Being constantly subject to innovationmeans that these industries are often being introduced to new technologies and techniques, or processes and procedures. Today, we at Global Health and Pharma are highlighting the work of NINAMedical, which has earned 2021’s Award for Excellence inNon-Invasive Surgery Solutions. Join us as we profile what it offers and how it has earned this coveted award title. NINA Medical Makes Marvels Working towards next-generation medicine, NINA Medical is focusing on the vision of noninvasive surgery. The general idea is to replace the doctor’s scalpel with a beam of energy that penetrates the body of the patient, inducing a controlled modification to a target tissue, in order to achieve a specific medical outcome. Non-invasive surgery has been gaining traction over the years, with many choosing this option over traditional surgery. NINA Medical develops a non-invasive technology for high-energy ultrasound radiation capable of burning a selected point inside the body. The company is an innovator in this field and as such, it was awarded the 2021 Award for Excellence in Non-Invasive Surgery Solutions by Global Health and Pharma Magazine. NINA Medical is founded on the motto of “Treatment Without Trauma”. The team is passionate about non-invasive solutions that are at the forefront of the medical technology. Delivering this high-energy ultrasound radiation beam is right there, spearheading what the medical industry is currently doing. The process works as follows: Ultrasound energy is transmitted and focused so that the intensity reaches extremely high values at the focal point, inducing a thermal effect at the focal point alone. This causes selective ablation to the target tissue, leaving the surrounding tissue intact. NINA Medical’s proprietary technology facilitates guided treatment by means of diagnostic ultrasound, meaning that the user can actually visualize the focal point inside the body in real-time. This enables the physician to control the high energy beam and bring the focal point to the target tissue. NINA Medical is gradually earning its reputation for being a pioneer in this emerging field of image guided high intensity focused ultrasound, otherwise known as HIFU. Being active in this field has allowed the company to introduce a set of patent-pending inventions that aim to boost the adoption of HIFU as an acceptable modality for non-invasive surgery. At present, although its product is still in the development phase, NINA Medical has a bright future ahead, especially in light of global trends leaning towards less invasive treatment solutions. Primary beneficiaries from the work being carried out by NINA Medical include men at the third age who suffer from symptoms of the enlarged prostate, also known as benign prostatic hyperplasia (BPH). Sometimes considered to be part of the normal ageing process of men, the condition affects more than 50% of men above age of 55. BPH is a progressive condition in which the prostate grows and gradually blocks the urethra, diminishing the flow of urine from the bladder. Symptoms include difficulties in urination, the frequent and urgent need to urinate, and nocturia, all of which have a negative effect on quality of life. Existing treatment options include medications as a firstline treatment and minimally invasive surgery as a secondline treatment. In more severe situations, surgery may be considered as well. Although medications are common, they do have side effects, not always tolerable by the patients. Patients usually cease medications within several years, either because of the unbearable side effects or due to degradation in pharmacological efficacy. At this stage, men start to search for options for minimally invasive surgery. Existing solutions span from supportive stent to steam injection, and they are all trans-urethral; that is, they use the urethra of the patient as a working channel for the insertion Shmuel Ben-Ezra, CEO

GHP / Q1 2021 13 of medical instrumentation. Since most men are reluctant to accept a trans-urethral procedure, the instinctive reaction will be to postpone the treatment. Alas, the chances for complications due to the untreated enlarged prostate grow with time. Complications may include recurring infections, permanent damage to the bladder and chronic kidney failure. “The introduction of the first non-invasive solution for BPH will encourage men to get treatment earlier” says Shmuel Ben-Ezra, CEO of NINA Medical. “With our Treatment Pillow, we will approach the prostate from the perineum, exploiting the acoustic window for ultrasound imaging and for focal therapy by HIFU thermal ablation”. This technology has the potential to change the medical marketplace, with future applications for cancer treatments. NINA Medical’s diverse team of professionals plays a pivotal role in the firm’s success, and have done so since day one. With a constant effort to strengthen its staff, patients can be confident that the company will continue to generate ideas and develop them into gamechanging applications. There is strength in scientific knowledge and insight, particularly on the Scientific Advisory Board of the firm. World-leading specialists in the field of urology, such as Professor Mark Emberton from the University College of London, are part of the Board, making it one of the best in the business. 2021 will undoubtedly be highlighted as a pivotal year for NINA Medical as the firm prepares for clinical trials, making full use of HIFU technology in a bid to help patients all over the world. Yet, with all the talk of future success, it is the here and now that the firm is celebrating. NINA Medical has come through a turbulent 2020, as have many other medical firms, but it has done so with a clear vision of where it is going next, and how it is going to continue to help A new era in men’s health and wellbeing people all over the world. NINA Medical is a truly outstanding firm, and deserves every success in its clinical trials and beyond. Company: Nina Medical Website:

14 GHP / Q1 2021 , Nov20247 The use of robotics has risenwithin the healthcare industry, offering medical practitioners exciting new options when it comes to serving their patients. The teamat Suturo are worthy winners of GHP’s 2021’s Award for Excellence in Patient Care & Safety – Spain. We take a closer look at how an innovative mindset has been key to achieving this success. Safety First Often, patients come to healthcare professionals in a particularly vulnerable position. They don’t know what is coming next, and want to know not only the way forward, but assurance that the way forward will be as painless as possible No one understands this like the team at Suturo, who have put many systems into place to ensure that not only they deliver high quality services, but can do so consistently to their many patients. Much of the work that Suturo undertakes is in the field of Urological Oncology and pelvic floor problems, using technology to provide a new way forward that sets the standard for the rest of the industry. Holding the values of innovation, of continually updating knowledge and the careful incorporation of the latest technological achievements incredibly close, the team are able to provide their patients with comprehensive solutions to their urological problems. No two patients are the same, and this means that personalized solutions must be designed to meet the needs of the client. By addressing the needs of the case as it arises, the team can adjust to create the most appropriate treatment regime for their patients. At Suturo, the aim is to address the entire healthcare process, from first diagnosis all the way through to the resolution of the disease. Many of the patients who comes through the team’s door are suffering from urological diseases such as cancer of the prostate, kidney and bladder alongside women with pelvic prolapse and patients with chronic pelvic pain such as pudendal nerve entrapment. They turn to Suturo because of the team’s celebrated embracing of technology. This means that patients are able to access equipment such as the Da Vinci Xi Robot, Holmium Laser, MRI/ Ultrasound fusion biopsy. The team also undertakes genetic studies in prostate cancer for the benefits of their patients. The value of the firm comes from its astonishingly talented team. Everyone who works at Suturo is a professional of the highest calibre and commitment. Hired because of their incredible qualifications, they represent the best in the business when it comes to urology, allowed to perform at the highest possible levels thanks to technology available to them. The technological revolution has affected the health industry significantly over the last few years. The team have seen an eruption in the world of genetic advances as well as increased demands from patients. They simply have higher expectations than ever before. Meeting these expectations, and trying to exceed them, is how the team have been able to ensure their success for so many years. In the future, the team intend to explore more of the potential that technology offers. Already, they are promoting an ambitious artificial intelligence project to improve attendance quality. The essential objective for its development and implantation is to improve patient safety by avoiding medical errors and to offer personalized medicine instantly. Through investigating these options, they can remain at the forefront of patient care and safety. Company: Suturo Contact: Manuel Ruibal Moldes Web: Email: [email protected]

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16 GHP / Q1 2021 , Oct20462 Based in Rockwall, Texas, The Retreat Restorative & Aesthetics is a cosmetic surgery practice specialising inminimally invasive procedures. By utilising cutting-edge technology, they provide next generation results withminimal downtime. Restoring Your Confidence The Retreat provide world class results in an upscale environment, but without the hassle of the big city. This is and has always been the team’s mission. Using primarily non-surgical techniques, The Retreat deliver the same results as plastic surgery, but without a long and drawn-out recovery process. Treating patients of all ages, they provide customised treatment plans based on each client’s needs. The practice is led by Dr. Joshua Baker, who believes that cosmetic treatments must be considerate of the patient’s overall wellbeing. Dr. Baker is a well-trained and exceptionally skilled cosmetic surgeon who has many specialties, including body sculpting, breast and buttock fat grafting, as well as a range of topical face and body treatments. He approaches each treatment holistically, considering numerous factors against the client’s aesthetic and wellness goals. The Retreat also offers a number of treatments which are solely geared towards wellness and health. These include IV vitamin therapy, anti-ageing therapy, and both male and female sexual health treatments. In combination with their best-inclass technology, the practice delivers a truly modern offering that enhances clients’ overall life experience by helping them to look and feel amazing. In cosmetic treatments, no implants are used, so all augmentation and fat-transfer procedures are completely natural. All injectables are also FDA-approved, ensuring the safety of any minimally invasive treatments. The innovative and contemporary methods used by Dr. Baker and his team provide a far less invasive solution to treatments that previously would have required excision surgery and lengthy recovery times. In the brief period that the practice has been running, they have already garnered trust in their community and have received nothing but positive feedback about their services. Clients profess to the staff’s friendliness, professionalism, and the fact that they go above and beyond. Many clients mention Dr. Baker’s calm and caring manner, which puts them at ease. The staff are informative, honest, and clear; ensuring that they know exactly what the client needs so that results can be delivered. When it comes to aesthetic and cosmetic treatments, clients need a practice they can trust. The aestheticians at The Retreat have shown complete transparency and are continuing to provide noticeable results time after time. Even the Covid-19 pandemic, which has threatened medical and aesthetic businesses everywhere, has not impeded their success. Dr. Joshua Baker commented, “No one has ever dealt with such an imposing and persistent crisis at a global level, but we are constantly looking for ways to innovate and make lemonade from our lemons.” It could be this entrepreneurial spirit and positive mindset that has helped bring so much success to The Retreat in the past year. From an outsider’s perspective, the frequency of business and positive experience feedback they have received make it seem like any other year; perhaps even better. One recent testimony claims that the clinic’s IV immunity boost helped them protect from illness during business travel, meaning that if anything clients have even more reasons to visit The Retreat during the pandemic. As well as their helpful and personable service, the practice’s wellness treatments are certainly helping them “make lemonade from lemons.” The Retreat team’s friendly, transparent, and skilled service has attracted clients from Dallas, Plano, and many other locations in the Dallas-Fort Worth area. The practice provides a serene atmosphere in a tranquil location where clients can relax and feel comfortable. This has enabled them to form natural connections in their community, becoming a trusted pillar of support for those with issues affecting their self-esteem. With their state-ofthe-art technology, optimism and unbeatable service, the future looks bright for The Retreat. Contact: Dr. Joshua Baker Company: The Retreat Restorative & Aesthetics Web Address: www.

GHP / Q1 2021 17 , Oct20363 Aerolase strives to bridge the gap in dermatology fromgoodmedicine to great medicine using laser technology. The company is one of the world’s leading laser skin health technology innovators. After over 20 years of dedicated research and development their lasers help skin health professionals deliver better outcomes and experiences for their patients. Global Skin Health Pioneers Using their patented technology, Aerolase deliver modern solutions to medical and aesthetic skin concerns. Their highly advanced laser technology is suitable for patients of any age or skin type, including patients with darker skin tones, who have been historically marginalised by past laser and light-based devices. Possessing an innate desire to solve the most common skin problems that patients face, the company aspires to meet unmet skin health needs with inclusive laser technology. Aerolase technology is the foundation for any successful medical aesthetic practice. Their solutions are modern and more effective than others in the industry, meaning that skin health professionals can more easily retain existing customers and attract new ones. The profitable treatment options they have created have disrupted many areas of the light-based technology and aesthetic medical fields. Aerolase’s consistent innovation allows them to produce more value for physicians and patients by addressing changing and growing skin health needs. A primary goal at Aerolase has been to confront the long-ignored problems of that face those with darker skin tones. In the past, these communities have been underserved by a lack of safety and efficacy achieved by laser and light-based devices. Aerolase educates the medical and aesthetic community at large so that they are better equipped to solve these issues. By sharing facts, activities and resources designed to educate, they have been reducing stigma and building connections. Physicians who treat patients with darker skin tones are understandably concerned about the documented risk for complications when using light-based devices to address melasma, acne, and other aesthetic or medical skin concerns. Patients may also be discouraged from seeking out laser therapy based on common perceptions that it is simply not available for them. Aerolase is challenging all preconceptions with their 650 Microsecond Technology®. The patented 650 Microsecond Technology® delivers an especially short pulse duration, which is unprecedented in the laser technology field. High amounts of energy are transmitted in this short duration, ensuring that the laser’s energy is restricted to the targeted chromophore and avoids damaging nearby skin. The short pulse duration also means that the treated area is not thermally over-stressed, providing a 5-50 times shorter epidermal laser energy exposure time. In combination these benefits create a solution that reduces the risk of burns or pigmentary changes and removes the pain that is associated with older generations of laser treatment technology. It also decreases chances of scarring during vascular condition treatments, and due to its low melanin absorption rate is safer and more comfortable for patients with darker skin. Aerolase invests in customer success. They have reached their position as a global leader in laser technology by enabling physicians to practice medical and aesthetic skin treatments more safely and inclusively. Their forward-thinking innovation allows Dermatologists, Plastic Surgeons, and Medical Spas to attract more customers and avoid excluding patients of different ages or skin types. Clinics that use Aerolase technology can provide safety-assured and tolerable treatments to their patients. Each product also comes with customer support programs, which includes training in every area of running a successful practice. From marketing and operations to clinical training, they seek to provide continuing support to ensure their customers’ success. Aerolase is truly dedicated to improving the lives of customers and their patients. By delivering the height of advanced laser technology, educating the skin health professional community, and supporting clinics, Aerolase have become a cornerstone of the medical aesthetic industry. Contact: Sean Johnson Company: Aerolase Web: