GHP Q2 2022

NEWS The new IGX-Track App adds seamless analysis of antibody panning campaigns to the IGX Platform ENPICOM, an innovative bioinformatics software company, announced the upcoming expansion of the capabilities of the IGX Platform to unlock seamless analysis of antibody panning data. This major development will allow researchers to analyze antibody display data in an intuitive and visual way, easily perform multi-dataset comparisons, and identify a diverse set of enriched candidates with the best characteristics. “Our customer-centric approach to product development gives us a close-up view of the complex analysis workflows required for antibody display screening and how a single, scalable tool can immensely improve speed of analysis and quality of the selected candidates.” said Jos Lunenberg, co-founder and Chief Executive Officer at ENPICOM. “Due to limited, inefficient workflows researchers often have to discard the vast majority of the available NGS data and focus on a small pool of the most frequent clones. We are launching the new IGX-Track App so that our customers can look beyond the tip of the iceberg and make informed decisions with a complete view of their data. Custom analysis workflows and visualizations can be created with a few clicks so scientists can simply select better antibodies faster.” Enabling streamlined enrichment analysis Display technologies empower antibody discovery by screening millions of candidates against potential targets. By including different panning round conditions and a variety of antigens, researchers can obtain a robust candidate pool with diverse binding profiles. However, complex analysis workflows – including operations like intersecting, joining, or subtracting datasets – that match the panning campaign design are needed to fully take advantage of the powerful combination of NGS and display screening. The new IGX-Track App extends the antibody discovery capabilities of the IGX Platform and provides a fast, flexible way to discover a diverse set of enriched candidates with the best characteristics. Scientists can effortlessly compose enrichment analysis workflows that match the design of their panning campaigns and discover candidates that otherwise would have been overlooked. Scientists using IGX-Track on the IGX Platform will be able to: • Track clones across panning rounds to identify highly enriched candidates through tabular views and interactive, user-defined visualizations. • Freely join, intersect, and subtract many datasets to match their panning campaign design. • Broaden their analysis beyond just the most frequent clones with the platform’s scalable, NGS-ready architecture. • Easily subtract irrelevant antibodies identified in control panning conditions from the candidates enriched on target. • Make fully informed choices, while avoiding bias, by overlaying accurate liability predictions, assay data, and more onto enrichment graphs. ENPICOM Launches Versatile Display Data Analysis Solution to Accelerate Antibody Selection While Maximizing Precision diabetes, ensuring they have equal access to this essential programme either in person or digitally. This is crucial so that everyone, irrespective of their personal circumstances or skills, can benefit from the lifestyle changes which can prevent the serious longterm effects of diabetes.” The British Medical Journal recently found that the NHS DPP achieves results that are comparable to the face-to-face programme. Findings presented at April’s Diabetes UK Conference showed that participation in the digital diabetes prevention programme was associated with clinically significant reductions in both HbA1c and weight at 6 and 12 months (−1.6 mmol/mol and −3.1 kg at 12 months for HbA1c and weight respectively). The complementary face-to-face service provided by LWTC is structured and designed to facilitate peer-to-peer learning and includes friends and family in the journey to building a healthier lifestyle. Programme Success and a New Phase of Expansion New data suggests that the NHS DPP resulted in a 7% reduction in the number of new diagnoses of Type 2 diabetes in England. Almost one million people have been referred to the programme since it was first launched in 2016, with participants who complete achieving an average weight loss of 3.3kg. Therefore Framework 3 – a third edition of the programme – has been launched following the conclusion of Framework 2 in April 2022. A new Framework provides an opportunity for re-procurement, meaning the NHS DPP continues to have the best partners to achieve its goals. This also provides an opportunity to expand the scale of the programme, build on previous frameworks’ experience, support patient choice, and continue to improve access to the programme. Liva and LWTC will go live with the programme in the eight additional contract regions on 1st August 2022. The digital health coaching experience Through Liva’s app, participants have access to a real human health coach, designing a personalised lifestyle change programme for each person based on their individual needs. After a live video kick-off, participants receive ongoing tailormade guidance, support and empathy through videos and texts in the app. They can track their progress real-time and engage with a support group of peers to keep them motivated. The programme has been proven to help prevent type 2 diabetes as 80% of participants with prediabetes reduce their HbA1c levels in 6 months. The physical health coaching experience Participants can join a small group of people who are also at risk of developing type 2 diabetes. In 13 sessions spread over nine months, a trained Coach will provide the motivation, resources, advice, and support participants need to increase physical activity and improve their diet. The programme is free and supports non-English speakers, and participants can even bring someone for extra support.